The 1954 Wilkes 160 was a Grand National (now Sprint Cup) event held at North Wilkesboro Speedway on October 24, 1954. It was the season finale. Hershel McGriff won his fourth event of the year, holding off Buck Baker. Despite finishing last (32nd), Lee Petty wound up winning the 1954 championship. Stats
- The race was shortened from 160 to 157 laps after a crash by Lou Figaro.